Table 1 Effect of oxaliplatin on morphometry of L5 DRG neurons with immunoreactivity for pNF-H, parvalbumin, NF-M or NF-H.
|  |  | Frequency of Immunoreactive Cells (%) | Mean Cell Body Area of Immunoreactive Cells (μm2) | Frequency of Small Cells (%) | Frequency of Medium Cells (%) | Frequency of Large Cells (%) |
|---|---|---|---|---|---|---|
pNF-H | Control | 21.0 ± 1.9 | 1259 ± 36 | 17.2 ± 1.7 | 67.2 ± 1.8 | 15.6 ± 2.3 |
|  | Oxaliplatin | 5.2 ± 0.3 | 696 ± 47 | 59.7 ± 3.8 | 39.5 ± 3.3 | 0.82 ± 0.5 |
| Â | Percent change | -75% | -45% | 247% | -41% | -95% |
| Â | P | <0.0002 | <0.0001 | <0.0001 | <0.0005 | <0.001 |
Parvalbumin | Control | 17.4 ± 1.9 | 1042 ± 31 | 40.2 ± 1.9 | 44.6 ± 1.8 | 15.5 ± 2.9 |
|  | Oxaliplatin | 18.2 ± 4.2 | 739 ± 75 | 59.3 ± 12 | 37.2 ± 5.7 | 2.9 ± 2.2 |
| Â | Percent change | 4.6% | -29% | 49% | -17% | -81% |
| Â | P | 0.82 | 0.047 | 0.09 | 0.35 | 0.008 |
NF-M | Control | 41.7 ± 4.0 | 997 ± 29 | 32.2 ± 2.2 | 63.6 ± 3.3 | 4.2 ± 1.6 |
|  | Oxaliplatin | 41.4 ± 4.6 | 888 ± 21 | 39.4 ± 4.5 | 59.0 ± 4.8 | 1.6 ± 0.3 |
| Â | Percent change | -1% | -11% | 22% | -7% | -62% |
| Â | P | 0.96 | 0.038 | 0.22 | 0.47 | 0.19 |
NF-H | Control | 96.0 ± 0.9 | 1068 ± 42 | 38.8 ± 6.8 | 46.0 ± 7.4 | 15.2 ± 0.8 |
|  | Oxaliplatin | 95.9 ± 1.0 | 765 ± 24 | 58.9 ± 1.8 | 37.4 ± 1.4 | 3.6 ± 0.6 |
| Â | Percent change | 0% | -28% | 52% | -19% | -76% |
| Â | P | 0.93 | 0.0033 | 0.045 | 0.32 | <0.001 |