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Table 1 Effect of oxaliplatin on morphometry of L5 DRG neurons with immunoreactivity for pNF-H, parvalbumin, NF-M or NF-H.

From: Oxaliplatin-induced loss of phosphorylated heavy neurofilament subunit neuronal immunoreactivity in rat DRG tissue

   Frequency of Immunoreactive Cells (%) Mean Cell Body Area of Immunoreactive Cells (μm2) Frequency of Small Cells (%) Frequency of Medium Cells (%) Frequency of Large Cells (%)
pNF-H Control 21.0 ± 1.9 1259 ± 36 17.2 ± 1.7 67.2 ± 1.8 15.6 ± 2.3
  Oxaliplatin 5.2 ± 0.3 696 ± 47 59.7 ± 3.8 39.5 ± 3.3 0.82 ± 0.5
  Percent change -75% -45% 247% -41% -95%
  P <0.0002 <0.0001 <0.0001 <0.0005 <0.001
Parvalbumin Control 17.4 ± 1.9 1042 ± 31 40.2 ± 1.9 44.6 ± 1.8 15.5 ± 2.9
  Oxaliplatin 18.2 ± 4.2 739 ± 75 59.3 ± 12 37.2 ± 5.7 2.9 ± 2.2
  Percent change 4.6% -29% 49% -17% -81%
  P 0.82 0.047 0.09 0.35 0.008
NF-M Control 41.7 ± 4.0 997 ± 29 32.2 ± 2.2 63.6 ± 3.3 4.2 ± 1.6
  Oxaliplatin 41.4 ± 4.6 888 ± 21 39.4 ± 4.5 59.0 ± 4.8 1.6 ± 0.3
  Percent change -1% -11% 22% -7% -62%
  P 0.96 0.038 0.22 0.47 0.19
NF-H Control 96.0 ± 0.9 1068 ± 42 38.8 ± 6.8 46.0 ± 7.4 15.2 ± 0.8
  Oxaliplatin 95.9 ± 1.0 765 ± 24 58.9 ± 1.8 37.4 ± 1.4 3.6 ± 0.6
  Percent change 0% -28% 52% -19% -76%
  P 0.93 0.0033 0.045 0.32 <0.001
  1. Animals were treated with oxaliplatin or drug vehicle alone (control group) twice per week for 8 weeks. Values represent the mean and standard error of the mean for 4 to 5 animals/group.