Figure 3
Formalin-induced nociception and its modulation by GABA B(1) agonist, baclofen, in GABA B(1) fl/fl and SNS-GABA B(1) -/- mice. (A) Time course of nocifensive behavior after the injection of 1% formalin into the hindpaw in SNS-GABAB(1) -/- mice and their control littermates. (B) Cumulative analysis of phase I (0-10 min) and phase II (10-60 min) of the formalin response shows no significant differences in both genotypes, SNS-GABAB(1) -/- and GABAB(1) fl/fl mice. Intraperitoneal injection of baclofen (2 mg/kg body weight) applied 30 minutes before intraplantar injection of formalin caused a reduction in both phases in GABAB(1) fl/fl as well as SNS-GABAB(1) -/- mice. (C) baclofen-induced modulation of the time course of the formalin responses foregoing by intraperitoneal injection of baclofen in GABAB(1) fl/fl and SNS-GABAB(1) -/-. PBS was injected in the control group. * indicates significant statistical difference (p < 0.05; ANOVA followed by post-hoc Fisher's test).