Behavior analysis of GABA
fl/fl and SNS-GABA
-/- mice in the CFA model of inflammatory pain. (A) Changes in paw withdrawal latency (in s) in response to noxious heat 12 hours and 1, 2, 4, 6 and 8 days following unilateral intraplantar injection of CFA. (B) Thermal hyperalgesia (changes in latency of paw withdrawal in response to noxious heat applied to the hindpaw plantar surface either before (basal) or at 12 h, and 1, 2, 4, 6 and 8 days) following unilateral intraplantar injection of CFA. Y axes represent the percent difference in paw withdrawal latency between the injected and uninjected paws calculated as (injected paw - uninjected paw) × 100/uninjected paw (negative values therefore indicate hyperalgesia). Comparison of response frequency to von Frey hairs in GABAB(1)
fl/fl (n = 6) and SNS-GABAB(1)
-/- (n = 6) mice prior to (C), 1 days (D) and 6 days (E) following intraplantar injection of CFA. (F) Summary of threshold (defined as a force eliciting a response frequency of at least 40%) prior to and at 12 hours and 1, 2, 4, 6 and 8 days following intraplantar injection of CFA.