Figure 5

Analysis of GABA _B(1) ^fl/fl and SNS-GABA _B(1) ^-/- in the Spared nerve injury model for neuropathic pain. (A) Latency of paw withdrawal to dynamic von Frey stimulation in GABA_B(1) ^fl/fl and SNS-GABA_B(1) ^-/- mice before and 3,7,9,16 and 23 days following spared nerve injury (SNI). (B) Latency of thermal responses via hot plate latency test (52°C) (C) Number of reactions to a 5°C cold stimulus (flinching, licking, jumping, and shaking) during an observation period of 90 seconds on a cold plate. (D) Response to plantar application of acetone in GABA_B(1) ^fl/fl and SNS-GABA_B(1) ^-/-. All data points represent mean ± SEM. Statistical significance was not reached between mice of the two genotypes (ANOVA).