Figure 3
From: Purinergic mechanosensory transduction and visceral pain
A. Spontaneous and distension-induced activity in ureter afferent fibres. Multifibre afferent responses to rapid distension. Note that background afferent activity occurs in bursts and that ureter distension results in an initial burst of discharge (circle) followed by a phase of maintained activity (bar). B. ATP can sensitise ureter afferent fibres. An example representative of distension-induced afferent activity before and following intraluminal application of increasing concentrations of ATP. c. TNP-ATP inhibits distension-induced afferent activity. A multifibre recording to show distension-induced afferent activity in control and in the presence of TNP-ATP. (Reproduced from [33], with permission of Elsevier.)