Figure 3

Regulation of expression of the cytokine receptor Ccr2 after L5 SNL correlated positively with the degree of tactile hypersensitivity. Each symbol represents one mouse of the AKR, CBA or B6 strain. Expression data, for individual mice, are plotted as: A, the raw signal intensity values associated with Ccr2 gene expression, and B, the log ratio of the signal intensity of the individual mouse divided by the average signal intensity of all sham operated mice of the same strain. Values for tactile hypersensitivity of the individual mice were normalized as indicated in the Methods, where increasing values indicate greater sensitivity. r = Pearson correlation coefficient, p = statistical significance of r, q =false discovery rate (FDR) coefficient associated with Ccr2 in the microarray analysis.