Figure 4

Regulation of expression of the TTX-R Na⁺ channel alpha subunit Scn11a after L5 SNL correlated negatively with the degree of tactile hypersensitivity. Each symbol represents one mouse of the AKR, CBA or B6 strain. Expression data, for individual mice, are plotted as: A, the raw signal intensity values associated with Scn11a gene expression, and B, the log ratio of the signal intensity of the individual mouse divided by the average signal intensity of all sham operated mice of the same strain. The value for tactile hypersensitivity for these mice was normalized as indicated in the Methods, where increasing values indicate greater sensitivity. r = Pearson correlation coefficient, p = statistical significance of r, q = false discovery rate (FDR) coefficient associated with Scn11a in the microarray analysis.