Correlational analysis for identifying genes whose regulation contributes to chronic neuropathic pain

Molecular Pain

Table 4 Correlational analysis of log ratio data from the L5DRG (nerve injured vs. sham) against across-strain measures of tactile allodynia (five strains analysis).

Affymetrix qualifier	Gene name *	Proposed gene function	r _P	p-value of r _P	r _S	p-value of r _S	q-value from FDR
1416827_at	Tbxas1	Thromboxane synthase	0.998	<0.001	1.000	<0.001	0.141
1450792_at	Tyrobp	Protein tyrosine kinase binding protein	0.997	<0.001	1.000	<0.001	0.217
1416001_a_at	Cotl1	Regulation of actin cytoskeleton	0.996	<0.001	1.000	<0.001	0.217
1427076_at	Mpeg1	Macrophage expressed gene	0.995	<0.001	0.900	0.037	0.241
1419483_at	C3ar1	Complement component receptor	0.994	0.001	1.000	<0.001	0.259
1423547_at	Lyzs	Lysozyme	0.993	0.001	1.000	<0.001	0.259
1438320_s_at	Mcm7	DNA replication licensing complex	0.993	0.001	0.900	0.037	0.259
1421477_at	Cplx2	Complexin 2	-0.993	0.001	-1.000	<0.001	0.259
1425108_a_at	BC004728	EST (expressed sequence tag)	0.992	0.001	1.000	<0.001	0.259
1437829_s_at	Eef2k	Transcribed locus	0.988	0.002	1.000	<0.001	0.424
1450842_a_at	Cenpa	Cell cycle regulator	0.988	0.002	1.000	<0.001	0.424
1427368_x_at	Fes	Feline sarcoma oncogene	0.986	0.002	1.000	<0.001	0.489
1436778_at	Cybb	Cytochrome, beta polypeptide	0.985	0.002	1.000	<0.001	0.490
1419943_s_at	Ccnb1	Mouse cyclin B1	0.984	0.002	1.000	<0.001	0.517
1424829_at	A830007P12Rik	EST	0.984	0.003	0.900	0.037	0.517
1416612_at	Cyp1b1	Cytochrome involved in angiogenesis	0.983	0.003	0.900	0.037	0.518

* Transcripts with Pearson correlation coefficient (r_P) among the highest observed are listed, along with their corresponding p-values, Spearman rank correlation coefficient (r_S) and p-values, and q-value from FDR analysis.

ISSN: 1744-8069