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Figure 4 | Molecular Pain

Figure 4

From: Differential regulation of immune responses and macrophage/neuron interactions in the dorsal root ganglion in young and adult rats following nerve injury

Figure 4

Reactive macrophages in L4/L5 adult rat dorsal root ganglia 7 days after spared nerve injury. The immunohistochemistry shows A) macrophages (IBA-1 marker, in red) forming clusters around the large (>25 μm) A-neurons (pink arrows), but not around small C-neurons (blue arrows); B) the same sections stained with NF200 (in green) to show A-neurons, the yellow arrow indicates a large A-neuron without macrophages; C) the merged image of IBA-1 and NF200 staining clearly shows the 'ring-like' structure of macrophages surrounding the A-neurons (pink arrows), while the small C-neurons (< 25 μm) has no macrophage ring (blue arrows); D) a graph showing the percentage of macrophage 'ring-like' formations in DRG neurons 7 days post SNI according to large and small sensory neurons. *: Statistical significance between A- and C-neurons is indicated (t-test, p < 0.001; n = 660 cells, pooled from 3 animals; power> 80%); SE: standard error, scale bar: 100 μm.

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Molecular Pain

ISSN: 1744-8069

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