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Table 2 Summary of putative new gene candidates implicated in the neuropathic pain model SNI at the dorsal root ganglia level.

From: Differential regulation of immune responses and macrophage/neuron interactions in the dorsal root ganglion in young and adult rats following nerve injury

Affymetrix ID Gene Name Gene Symbol Group Functionality
1368224_at Serine (or cysteine) peptidase inhibitor, clade A, member 3N SERPINA3N IS Inflammation [5961]
1369191_at Interleukin 6 IL-6 IS Macrophage in neuropathic pain, inflammation [35]
1379631_at Colony stimulating factor 1 (macrophage) CSF-1 IS Specific factor for macrophages [7375]
1387982_at Toll-like receptor 4 TLR4 IS Inflammation/Immune response/pain [46, 47]
1368000_at Complement component 3 C3 IS Apoptosis, caspase activation, complement activation, pain processes [5052]
1367973_at Macrophage chemoattractant protein-1 MCP-1/CCL2 IS Chemoattractant, pain processes [4143]
1370449_at Purinergic receptor P2Y, G-protein coupled, 14 P2RY14 IS Immune response [49]
1375633_at Chloride intracellular channel 1 CLIC-1 IS Cell cycle progress/Microglia activation [48]
1387690_at Caspase 3 CASP3 Apop Apoptosis, inflammation, pain processes [7678]
1373623_at Inositol 1,4,5-trisphosphate 3-kinase C ITPKC ST Ca2+ homeostasis [69, 79]
1387809_at Mitogen-activated protein kinase kinase 6 MAP2K6 ST Modulation of p38 MAPK [62]
1369737_at cAMP responsive element modulator CREM RNA
Crem isoform, c-fos regulation, expressed after thermal stimulation [68]
1370678_s_at Monoamine oxidase A Maoa NS p38/caspase 3 apoptosis pathways [63]
1368657_at Matrix metallopeptidase 3 MMP3 Other Remodellation, lymphocytes signalling, inflammation, pain processes [57, 80, 81]
1368590_at Matrix metalloproteinase 16 MMP16 Other Matrix remodelling [54, 82]
1368487_at Serine (or cysteine) proteinase inhibitor, clade B, member 2 SERPINB2 Other Expressed by DRGs after injury [83]
  1. The table shows the identified gene by Affy_ID, name, gene symbol, Go term classification group and its putative function. IS: immune system; Apop: apoptosis; ST: signal transduction; NS: nervous system; RNA mod: RNA modulation.