Table 2 Summary of putative new gene candidates implicated in the neuropathic pain model SNI at the dorsal root ganglia level.
Affymetrix ID | Gene Name | Gene Symbol | Group | Functionality |
|---|---|---|---|---|
1368224_at | Serine (or cysteine) peptidase inhibitor, clade A, member 3N | SERPINA3N | IS | |
1369191_at | Interleukin 6 | IL-6 | IS | Macrophage in neuropathic pain, inflammation [35] |
1379631_at | Colony stimulating factor 1 (macrophage) | CSF-1 | IS | |
1387982_at | Toll-like receptor 4 | TLR4 | IS | |
1368000_at | Complement component 3 | C3 | IS | Apoptosis, caspase activation, complement activation, pain processes [50–52] |
1367973_at | Macrophage chemoattractant protein-1 | MCP-1/CCL2 | IS | |
1370449_at | Purinergic receptor P2Y, G-protein coupled, 14 | P2RY14 | IS | Immune response [49] |
1375633_at | Chloride intracellular channel 1 | CLIC-1 | IS | Cell cycle progress/Microglia activation [48] |
1387690_at | Caspase 3 | CASP3 | Apop | |
1373623_at | Inositol 1,4,5-trisphosphate 3-kinase C | ITPKC | ST | |
1387809_at | Mitogen-activated protein kinase kinase 6 | MAP2K6 | ST | Modulation of p38 MAPK [62] |
1369737_at | cAMP responsive element modulator | CREM | RNA mod | Crem isoform, c-fos regulation, expressed after thermal stimulation [68] |
1370678_s_at | Monoamine oxidase A | Maoa | NS | p38/caspase 3 apoptosis pathways [63] |
1368657_at | Matrix metallopeptidase 3 | MMP3 | Other | Remodellation, lymphocytes signalling, inflammation, pain processes [57, 80, 81] |
1368590_at | Matrix metalloproteinase 16 | MMP16 | Other | |
1368487_at | Serine (or cysteine) proteinase inhibitor, clade B, member 2 | SERPINB2 | Other | Expressed by DRGs after injury [83] |