Figure 5
From: Peripheral non-viral MIDGE vector-driven delivery of β-endorphin in inflammatory pain
Swim stress and POMC-MIDGE-NLS effects on inflammatory pain. Paw pressure thresholds (PPT) were measured at 4 days after induction of inflammation (white bars), then control MIDGE-NLS (50 μg; gray bars) or POMC-MIDGE-NLS (50 μg; black bars) were injected into inflamed paws and PPT were re-evaluated 24 h later (baseline, BL). Next, rats were exposed to cold water swim stress and PPT were re-examined 1 min and 5 min later. *p < 0.05, compared with the BL of control MIDGE-NLS; +p < 0.05, compared with respective BL (two-way repeated measures ANOVA and Bonferroni t-test); #p < 0.001, compared with respective PPT of inflamed paws before vector injections (depicting the development of inflammatory hyperalgesia) (paired t-test).