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Figure 6 | Molecular Pain

Figure 6

From: Peripheral non-viral MIDGE vector-driven delivery of β-endorphin in inflammatory pain

Figure 6

Effects of intraplantar POMC-MIDGE-NLS encoding multiple copies of β-endorphin (END) on inflammatory pain. Paw pressure thresholds (PPT) were measured at 4 days after induction of inflammation (white bars), control MIDGE-NLS, POMC-MIDGE-NLS and vectors with 1-3 copies of END (1-3xEND-MIDGE-NLS) (each at 50 μg) were injected into both hind paws and PPT were re-evaluated 24 h later (black bars). *p < 0.05, compared with control MIDGE-NLS at 24 h after its injection (t-test); #p < 0.001, compared with respective PPT of inflamed paws before vector injections (depicting the development of inflammatory hyperalgesia) (paired t-test).

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