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Figure 7 | Molecular Pain

Figure 7

From: Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury

Figure 7

Summary of alterations seen in firing patterns in ACC pyramidal neurons after neuropathic pain. A-B, Plot of the initial discharge frequency measured from the 1st interspike interval at different stimulation intensities of depolarizing current (100--350 pA, 400 ms). C-D, Plot of the steady-state discharge frequency measured from the last interspike interval at different stimulation intensities of depolarizing current (100--350 pA, 400 ms). E-F, Plot of the number of APs at different stimulation intensities of depolarizing current (100--350 pA, 400 ms); (A), (C) and (E) show relationships for IM neurons; (B), (D) and (F) for RS and IB neurons. Note that in IM cells, the initial discharge frequencies (*P < 0.05, F 1,389 = 23.34, two-way ANOVA) and the number of APs (*P < 0.05, F 1,389 = 13.47, two-way ANOVA) attained in neuropathic pain cells are greater than those seen in controls. Error bars represent S.E.M. Control data was collected from 20 RS, 36 IM and 25 IB neurons. Neuropathic pain data was collected from 13 RS, 29 IM and19 IB cells, respectively.

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