Effects of CK1 inhibitor IC261 on SNL-induced neuropathic pain behaviors. (A, B) Effects of intrathecal injection of IC261 on mechanical allodynia (A) and thermal hyperalgesia (B). (C, D) Effects of intrathecal injection of 3% DMSO used for dissolving IC261 on mechanical allodynia (C) and thermal hyperalgesia (D). Paw withdrawal threshold to mechanical stimulation and paw withdrawal latency to thermal stimuli are plotted against the time after intrathecal injection of IC261 or DMSO. Data are mean ± SEM (n = 6-13). *p < 0.05, ***p < 0.001, compared with pre-drug (at 0 h) data (one-way ANOVA followed by Dunnett's post hoc test). C57BL/6J mice two weeks after SNL injury were used.