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Table 1 Summary of the effects of microinjection of IL-10, fluorocitrate and minocycline into the Vi/Vc or caudal Vc zone on CFA-induced masseter or cutaneous hyperalgesia.

From: Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors

  IL-10 Fluorocitrate Minocycline Saline
  Vi/Vc Vc Vi/Vc Vc Vi/Vc Vc Vi/Vc Vc
Masseter-CFA         
Ipsilateral + + + + + + - -
Contralateral + - + - + - - -
Skin-CFA         
Ipsilateral - + - + - + - -
Contralateral - - - - - - - -
Naive         
Ipsilateral - - - - - - - -
Contralateral - - - - - - - -
  1. Plus signs (+) indicate significant attenuation of hyperalgesia. Minus signs (-) indicate a lack of effect on hyperalgesia. Note that intra-Vi/Vc injection of the three agents attenuated bilateral hyperalgesia associated with masseter inflammation without an effect on cutaneous hyperalgesia. Intra-Vc injection of the three agents only attenuated ipsilateral hyperalgesia after both masseter and cutaneous inflammation.