Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors

Table 1 Summary of the effects of microinjection of IL-10, fluorocitrate and minocycline into the Vi/Vc or caudal Vc zone on CFA-induced masseter or cutaneous hyperalgesia.

	IL-10		Fluorocitrate		Minocycline		Saline
	Vi/Vc	Vc	Vi/Vc	Vc	Vi/Vc	Vc	Vi/Vc	Vc
Masseter-CFA
Ipsilateral	+	+	+	+	+	+	-	-
Contralateral	+	-	+	-	+	-	-	-
Skin-CFA
Ipsilateral	-	+	-	+	-	+	-	-
Contralateral	-	-	-	-	-	-	-	-
Naive
Ipsilateral	-	-	-	-	-	-	-	-
Contralateral	-	-	-	-	-	-	-	-

Plus signs (+) indicate significant attenuation of hyperalgesia. Minus signs (-) indicate a lack of effect on hyperalgesia. Note that intra-Vi/Vc injection of the three agents attenuated bilateral hyperalgesia associated with masseter inflammation without an effect on cutaneous hyperalgesia. Intra-Vc injection of the three agents only attenuated ipsilateral hyperalgesia after both masseter and cutaneous inflammation.

ISSN: 1744-8069