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Figure 2 | Molecular Pain

Figure 2

From: Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: the preventive effect of ketamine

Figure 2

Effects of remifentanil on PWTL during the postoperative period and the intervention of ketamine. Ketamine (10 mg/kg, 0.1 ml) or saline was subcutaneously injected 30 min before surgery. Under sevoflurane anesthesia, remifentanil (0.04 mg/kg, 0.4 ml) or saline was subcutaneously infused in the absence or presence of the right hind paw incision during a period of 30 min. PWTL was evaluated at 24 h before incision and at 2 h, 6 h, 24 h and 48 h after surgery. Number of rats per group was twelve. Data are expressed as means ± SD. * P < 0.01 vs baseline, # P <0.01 vs group C, P <0.05 vs group I, P < 0.01 vs group R.

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