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Figure 3 | Molecular Pain

Figure 3

From: Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: the preventive effect of ketamine

Figure 3

Typical photomicrographs representing tyrosine phosphorylation of NR2B immunoreactive neurons in the superficial dorsal horn. The L4-L5 spinal cords for analysis were collected at 48 h after the surgery. In preparations of control group, hardly any tyrosine phosphorylation of NR2B immunoreactive neurons was found in the dorsal horn region (A). In preparations of rats with incision receiving saline or ketamine, moderate tyrosine phosphorylation of NR2B immunoreactive neurons was obtained in the superficial dorsal horn (Laminae I-II) at the L4-L5 spinal cord, ipsilateral to the incision (B and C). The number of tyrosine phosphorylation of NR2B immunoreactive neurons were drastically upregulated in rats receiving infusion of remifentanil (D), which was remarkably inhibited by pretreatment with ketamine (E). Magnification: × 100. Scale bar = 100 μm.

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Molecular Pain

ISSN: 1744-8069

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