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Figure 1 | Molecular Pain

Figure 1

From: Effects of removal of dietary polyunsaturated fatty acids on plasma extravasation and mechanical allodynia in a trigeminal neuropathic pain model

Figure 1

Diet modifies differently mechanical response thresholds. Nociceptive responses to Von Frey hairs applied to the vibrissal pads in rats fed RD or MD at pre-surgery time point and at three time intervals after a CCI-IoN performed on the left side. Data represent the mean Ā± SEM of n = 15 (Pre-surgery and 8 dps) and n = 9 (15 and 26 dps) animals. The unilateral constriction evoked in both diet groups a highly significant decrease in response threshold that evolved with time in the ipsilateral (p < 0.001) but not the contralateral side. Differences between diet groups were highly significant ipsilaterally to the surgery at 8 dps (* p = 0.005), and showed statistical tendency at 15 dps (p = 0.059). Side differences were significant (arrows) at all postsurgery testing times (8 dps, p = 0.008; 15 dps, p = 0.01; 26 dps, p = 0.005) in the MD group, but only at 15 dps (p = 0.04) and 26 dps (p = 0.001) in the RD group.

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Molecular Pain

ISSN: 1744-8069

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