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Figure 2 | Molecular Pain

Figure 2

From: Ryanodine receptors contribute to the induction of nociceptive input-evoked long-term potentiation in the rat spinal cord slice

Figure 2

Involvement of RyR in the induction of LTP of fEPSPs in the spinal dorsal horn in vivo. The spinal LTP was blocked by high concentration of ryanodine (1 mM, 10 μl) intrathecally applied 30 min before tetanic stimulation (P < 0.001, vs. vehicle) (control n = 5; ryanodine n = 6) in the spinal cord in vivo. Representative original recordings (average of six consecutive traces) were shown below from the time points as indicated.

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Molecular Pain

ISSN: 1744-8069

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