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Figure 3 | Molecular Pain

Figure 3

From: Ryanodine receptors contribute to the induction of nociceptive input-evoked long-term potentiation in the rat spinal cord slice

Figure 3

Reversal of L-NAMA-induced inhibition of LTP of fEPSP by cADPR, an endogenous agonist of the RyR. Perfusion with 50 μM L-NAME for 1 h before HFS of LT inhibited the induction of LTP (P < 0.001), which was reversed by co-application of L-NAME and 5 μM cADPR for 1 h before HFS (P < 0.001) (control, n = 5; L-NAME, n = 6; L-NAME + cADPR, n = 5).

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Molecular Pain

ISSN: 1744-8069

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