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Table 1 Gene expression of kinin receptors, TRPV1 and NFκB:

From: Kinin B1 receptors contributes to acute pain following minor surgery in humans

 

Placebo

Ketorolac

 

Pre-surgery

(Average ΔCt)

Post-surgery

(Average ΔCt)

Fold change*

(P value)

Pre-surgery

(Average ΔCt)

Post-surgery

(Average ΔCt)

Fold change*

(P value)

B 1 receptor

(BDKRB1)

17.4 ± 3.6

16.2 ± 3.6

2.5 ± 0.9

(p < 0.0001)

18.6 ± 3.4

17.4 ± 3.5

2.4 ± 0.8

(p < 0.0001)

B 2 receptor

(BDKRB2)

14.8 ± 3.0

13.8 ± 2.9

2.0 ± 0.6

(p < 0.0001)

15.6 ± 2.7

14.7 ± 2.7

1.9 ± 0.5

(p < 0.0001)

NFκB

17.3 ± 0.6

17.0 ± 0.4

1.3 ± 1.2

(p = 0.027)

17.3 ± 0.5

17.0 ± 0.7

1.4 ± 0.8

(p = 0.042)

TRPV1

18.8 ± 2.9

19.8 ± 2.7

-2.2 ± 0.9

(p < 0.0001)

19.5 ± 2.7

20.7 ± 2.9

-2.6 ± 1.1

(p < 0.0001)

  1. Data are presented as mean ± S.D.; n = 13-15 per group.
  2. *Fold change is calculated as 2-ΔΔCt, Average ΔCt is the normalized cycle threshold in reference to the endogenous control (18S rRNA). Data were analyzed using paired t test.