Figure 2
From: Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in mice
Relative gene expression of nNOS (A), iNOS (B) and eNOS (C) in the ipsilateral plantar skin in mice receiving CFA compared to control mice receiving NS (NS + CFA vs NS + NS). NNOS (A) and eNOS (C) gene expression was increased at 6 h (***P < 0.001), followed by a rapid decline to baseline levels at 16 and 24 h, after CFA. INOS gene expression was increased at 6 h, and peaked at 24 h, after CFA (B, **P < 0.01 and ***P < 0.001). At each time point n = 4.