Figure 3
From: Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in mice
Relative gene expression of TNF (A), IL-1β (B) and IL-10 (C) in the ipsilateral plantar skin in mice receiving CFA compared to control mice receiving NS (NS + CFA vs NS + NS). Note the rapid increase at 6 h, followed by a second rise for TNF and IL-1β at 24 h and a decline for IL-10 at 16 and 24 h, after CFA (**P < 0.01 and ***P < 0.001). At each time point n = 4.