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Figure 2 | Molecular Pain

Figure 2

From: TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats

Figure 2

In uninjured rats, (A) systemic administration of A-967079 (30 μmol/kg, i.v.) reduced WDR responses to noxious pinch (28 mm mini bulldog clamp for 10 sec), but not to 10-g von Frey stimulation (n = 5-7 per group) of the RF on the hind paw. (B) Spontaneous firing of WDR neurons was unaltered by A-967079 injection to uninjured rats (n = 7-12 per group). Representative ratemeters showing the responses of a single WDR neuron to; (C) 10-g von Frey hair stimulation (15 sec), and (D) a noxious pinch (28 mm mini bulldog clamp for 10 sec) both before and after injection of A-967079 (30 μmol/kg, i.v.) to uninjured rats. VF = 10-g von Frey hair stimulation, P = noxious pinch (mini bulldog clamp). Since vehicle did not alter WDR firing in animals receiving either a von Frey (n = 5) or pinch stimulus (n = 2), this data was combined for comparison. *p < 0.05, vs. baseline firing; +p < 0.05 vs. vehicle-treated group (Fisher's LSD).

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Molecular Pain

ISSN: 1744-8069

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