Figure 5

(A) Systemic administration of A-967079 (30 μmol/kg, i.v.) reduced NS responses to a noxious pinch (28 mm mini bulldog clamp for 10 sec) in both uninjured and CFA-inflamed rats (n = 5-6 per group). (B) Representative ratemeters showing the responses of a single NS neuron to noxious pinch (10 sec) stimulation of the hind paw in uninjured (left), and CFA-inflamed (right) rats before and after injection of A-967079 (30 μmol/kg, i.v.). P = 10 sec pinch (mini bulldog clamp) stimulation. Since vehicle did not alter NS firing in CFA (n = 3) or uninjured animals (n = 2), this data was combined for comparison **p < 0.01 vs. baseline firing; ⁺p < 0.05, ⁺⁺p < 0.01 vs. vehicle-treated group (Fisher's LSD).