Figure 6

In OA and OA-sham rats, systemic administration of A-967079 (30 μmol/kg, i.v.) reduced (A) the responses of WDR neurons high-intensity von Frey hair stimulation (300 g for 10 s) of the knee joint, but did not alter the (B) spontaneous firing of WDR neurons (n = 7-8 per group). Since vehicle did not alter WDR firing in OA (n = 5) or OA-sham rats (n = 2), this data was combined for comparison. *p < 0.05, **p < 0.01 vs. baseline firing; ⁺p < 0.05, ⁺⁺p < 0.01 vs. vehicle-treated group (Fisher's LSD).