Figure 4

Cisplatin-treated mice show reduced body weight and exploratory activity following each drug treatment cycle. (A) Mean body weight of TRPV1^-/- and wild-type mice is reduced after cisplatin drug treatment. (B) Mean horizontal distance traveled in 20 min is reduced after each cisplatin treatment cycle from TRPV1^-/- and wild-type mice. Data represent the mean ± SEM, n = 7 mice/group (*P < 0.05, ***P < 0.01, ***P < 0.001, two-way ANOVA followed with Bonferroni post hoc analysis; two-tailed unpaired T test for genotypes).