Skip to main content
Figure 8 | Molecular Pain

Figure 8

From: Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain

Figure 8

After several months of diabetes, microglia accumulation can be noted within dorsal spinal cord and to a lesser degree within thalamic nuclei. Compared to non-diabetic age-matched mice (A), immunohistochemistry identified a mild but significant accumulation of microglia within the thalamus after 5 months of diabetes (B). Microglial accumulation and activation (evaluated qualitatively) was more substantial in the dorsal spinal cord of diabetic mice. Treatment with intranasal high dose cannabidiol (C) attenuated the microglial accumulation identified in age-matched diabetic mice reciving no intervention (D) or receiving intranasal (E) or intraperitoneal (F) WIN55212-2 (see Tables 2 and 3). Bar = 50 μm

Back to article page

Molecular Pain

ISSN: 1744-8069

Contact us