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Figure 2 | Molecular Pain

Figure 2

From: Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats

Figure 2

Effects of intrathecal atropine, phenoxybenzamine or methysergide in the incision-induced Fos-like immunoreactivity in lamina V. The experiments utilized 4-8 non-incised and non-catheterized anesthetized rats (A), non-incised and catheterized rats treated intrathecally with 5 μl of saline (AS), incised and catheterized rats treated intrathecally with 5 μl of saline (ASI), 30 μg/5 μl of atropine (ATR), 20 μg/5 μl of phenoxybenzamine (PBZ), or 30 μg/5 μl methysergide (MET). Surgical incision of the right hind paw was performed 3 h after PBZ or 15 min after the remaining antagonists. The number of Fos-like immunoreactive (Fos-LI) cells/0.2 mm2 are shown for lamina V of ipsilateral (a) or contralateral (b) spinal dorsal horn. Bars are mean ± S.E.M. of the number of Fos-LI cells/0.2 mm2 found in three sections taken from each rat. P < 0.05 compared to A (+), ASI (*) or AS (#).

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