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Figure 5 | Molecular Pain

Figure 5

From: Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats

Figure 5

Effects of intrathecal LY278,584, ketanserin or methiothepin in the incision-induced Fos-like immunoreactivity in lamina I/II. The experiments utilized 4-8 non-incised and non-catheterized anesthetized rats (A), non-incised and catheterized rats treated intrathecally with 5 μl of saline (AS), incised and catheterized rats treated intrathecally with 5 μl of saline (ASI), 100 μg/5 μl of LY 278,584 (LY), 30 μg/5 μl of ketanserin (KET) or 1,5 μg/5 μl of methiothepin (MEP). Surgical incision of the right hind paw was performed 15 min after each antagonist. The number of Fos-like immunoreactive (Fos-LI) cells/0.2 mm2 are shown for lamina I/II of ipsilateral (a) or contralateral (b) spinal dorsal horn. Bars are mean ± S.E.M. of the number of Fos-LI cells/0.2 mm2 found in three sections taken from each rat. P < 0.05 compared to ASI (*) or AS (#).

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Molecular Pain

ISSN: 1744-8069

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