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Table 1 Effects of antagonists in the incision-induced increase of Fos-like immunoreactivity in the rat spinal cord

From: Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats

Antagonists

LI/LII

LV

LX

 

ipsi

contra

ipsi

contra

 

Atropine (muscarinic)

-

-

-

↑*

-

Phenoxybenzamine (α-adrenergic)

-

-

-

-

-

Methysergide (5-HT1/2B/2C)

↓*

-

↓#

↓#

↓#

LY 278,584 (5-HT3)

-

-

-

↓*

↓*

Ketanserin (5-HT2A)

↓*

-

-

↓*

↓*

Methiothepin (5-HT1/2A/2C/5/6/7)

↓*

-

↓*

↓*

↓*

  1. Antagonists were injected intrathecally. Abbreviations: ipsi = ipsilateral and contra = contralateral to the incised hind paw; ↓ = decrease and ↑ = increase of the effect produced by the incision on the Fos-like immunoreactivity. (*) Significantly different from intrathecal saline-treated incised rats. (#) Abolished the significance of the incision-induced increase of Fos-like immunoreactivity but did not differ significantly from intrathecal saline-treated incised rats.