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Figure 3 | Molecular Pain

Figure 3

From: An improved behavioural assay demonstrates that ultrasound vocalizations constitute a reliable indicator of chronic cancer pain and neuropathic pain

Figure 3

Analysis of the effects of analgesics on ultrasound vocalizations (USVs) and evoked mechanical hypersensitivity. (A and B) C3H/HeNCrl mice following implantation of sarcoma cells (tumour) in the heel bone were sub-cutaneously injected with fentanyl (0.1 mg/kg) or vehicle 15 min prior to the measurement of USVs (50 kHz) or von Frey responses (n = 6 mice/group). (C and D) SNI-treated C57Bl6 mice were injected intraperitoneally with gabapentin (30 mg/kg) or vehicle 1 h prior to measurement of USVs (50 kHz) or von Frey responses applied to the plantar surface (n = 6 mice/group). * denoted p < 0.05 as compared to drug-treated group at the corresponding time points after SNI/tumour implantation; ANOVA followed by post-hoc Fisher's test.

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Molecular Pain

ISSN: 1744-8069

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