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Figure 3 | Molecular Pain

Figure 3

From: Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behavior

Figure 3

P2Y Gi agonists inhibit depolarization-evoked increases in intracellular Ca++. Fura-2 Ca++ imaging was used to measure the effect of P2Y receptor agonists on Ca++ transients evoked by administration of 50 mM K+. Application of ADP (100 μM) for 3 minutes reduced subsequent depolarization-evoked transients in wildtype (A) and P2Y1-/- (B) mice. The P2Y13 agonist IDP (C) and the P2Y14 agonist UDPG (D) also inhibited depolarization-evoked transients.

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Molecular Pain

ISSN: 1744-8069

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