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Figure 1 | Molecular Pain

Figure 1

From: Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons

Figure 1

Up-regulation of PAP-I in rat DRGs after peripheral inflammation. (A) RT-PCR shows the increases in PAP-I mRNA levels in L4 and L5 DRGs after intraplantar CFA injection. (B) In situ hybridization shows that a few small neurons contain PAP-I mRNA in the DRG of normal rats. Two days after intraplantar CFA injection, the number of PAP-I mRNA-containing DRG neurons is markedly increased. Scale bar = 200 μm. (C) Time course of the up-regulated expression of PAP-I following CFA-induced inflammation shows that the increase in the number of PAP-I mRNA-containing DRG neurons reaches the peak level 2 days after inflammation and, then, is gradually reduced. Quantification was performed on 2~3 sections for each DRG from at least three animals at each time point. * P < 0.05, ** P < 0.01 versus control. (D) The PAP-I mRNA-containing neurons are mostly small DRG neurons (neuronal cross-section area < 900 μm2, n = 446).

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