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Figure 3 | Molecular Pain

Figure 3

From: Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons

Figure 3

Increase in PAP-II immunostaining in rat DRGs after peripheral inflammation. (A) Immunohistochemistry shows that the number of small DRG neurons immunostained for PAP-II is apparently increased 2 days after CFA injection. (B) The percentage of PAP-II-immunostained small DRG neurons is significantly increased from 3.3 ± 1.2% in the control DRGs to 27.6 ± 1.5% in the DRGs 2 days after peripheral inflammation. Such an increase of PAP-II-positive DRG neurons is reduced 4 days after inflammation, but remains at the low level 7 days after inflammation. Scale bar = 50 μm. ** P < 0.01 versus control (n = 7 rats).

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