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Figure 4 | Molecular Pain

Figure 4

From: Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons

Figure 4

Distribution of PAP-II in subsets of small DRG neurons 2 days after inflammation. (A) Double-immunofluorescence staining shows that in the rat DRG the majority of PAP-II-positive small DRG neurons do not contain CGRP, but are positive for IB4 2 days after CFA injection. Most PAP-II-containing DRG neurons are immunostained for peripherin. There is no co-localization of PAP-II and Trk-B in DRG neurons. PAP-II-positive neurons co-expressing other molecules, PAP-II-negative neurons but containing other molecules and PAP-II-positive neurons negative for other molecules are indicated by double arrowheads, single arrowhead and arrow, respectively. Scale bar = 50 μm. (B) Quantitative analysis shows that 26.3 ± 3% of PAP-II-positive DRG neurons (n = 352) co-express CGRP 2 days after peripheral inflammation, and 76.7 ± 1.4% (n = 399) stained for IB4. Most PAP-II-containing DRG neurons (89.8 ± 3.3%; n = 293) are immunostained for peripherin.

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