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Table 2 Parameters of steady-state slow-inactivation of WT, P1308L, and V1298F NaV1.7R channels.

From: Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel NaV1.7 produce distinct pain disorders

 

Steady-state slow inactivation

 

V 1/2, slow

k

R resist (%)

n

WT

-63.8 ± 1.7

12.6 ± 0.3

14.0 ± 1.2

14

P1308L

-68.4 ± 1.2

10.5 ± 0.3*

19.1 ± 1.4*

10

V1298F

-57.8 ± 1.1*

9.2 ± 0.3*

25.6 ± 1.5*

12

  1. * p < 0.05 P1308L or V1298F channels vs WT NaV1.7R channels.