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Table 2 Parameters of steady-state slow-inactivation of WT, P1308L, and V1298F NaV1.7R channels.

From: Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel NaV1.7 produce distinct pain disorders

  Steady-state slow inactivation
  V 1/2, slow k R resist (%) n
WT -63.8 ± 1.7 12.6 ± 0.3 14.0 ± 1.2 14
P1308L -68.4 ± 1.2 10.5 ± 0.3* 19.1 ± 1.4* 10
V1298F -57.8 ± 1.1* 9.2 ± 0.3* 25.6 ± 1.5* 12
  1. * p < 0.05 P1308L or V1298F channels vs WT NaV1.7R channels.