From: Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel NaV1.7 produce distinct pain disorders
Steady-state slow inactivation
V 1/2, slow
k
R resist (%)
n
WT
-63.8 ± 1.7
12.6 ± 0.3
14.0 ± 1.2
14
P1308L
-68.4 ± 1.2
10.5 ± 0.3*
19.1 ± 1.4*
10
V1298F
-57.8 ± 1.1*
9.2 ± 0.3*
25.6 ± 1.5*
12