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Table 3 Current clamp properties of DRG neurons transfected with WT, P1308L, or V1298F NaV1.7R construct.

From: Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel NaV1.7 produce distinct pain disorders

Construct

n

Rinput(MΩ)

RMP (mV)

Threshold (pA)

WT

38

605 ± 57

-55.9 ± 1.1

188 ± 14

P1308L

50

749 ± 70

-52.4 ± 1.1

122 ± 10*

V1298F

27

598 ± 46

-55.1 ± 1.5

154 ± 18

  1. * p < 0.05 vs WT NaV1.7R channels.
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Molecular Pain

ISSN: 1744-8069

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