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Table 3 Current clamp properties of DRG neurons transfected with WT, P1308L, or V1298F NaV1.7R construct.

From: Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel NaV1.7 produce distinct pain disorders

Construct n Rinput(MΩ) RMP (mV) Threshold (pA)
WT 38 605 ± 57 -55.9 ± 1.1 188 ± 14
P1308L 50 749 ± 70 -52.4 ± 1.1 122 ± 10*
V1298F 27 598 ± 46 -55.1 ± 1.5 154 ± 18
  1. * p < 0.05 vs WT NaV1.7R channels.