Figure 1

Analysis of the voltage dependence of NMDA receptors expressed in EGFP+ and EGFP- cells in the presence of 100 μM Mg²⁺. A, the current - voltage relationship recorded at the peak response to NMDA application in an EGFP+ and an EGFP- neuron. The maximal inward current (MIC) and voltage of maximal inward current (VMIC) are indicated by dashed lines. The conductance of NMDA receptors at -90 mV (g(-90 mV)) and conductance of maximal inward current (g(MIC)) are indicated by dotted lines. B, average g(-90 mV)/g(MIC) in EGFP+ and EGFP- interneurons (*P < 0.05, upper box) and the average VMIC in EGFP+ and EGFP- interneurons (*P < 0.05, lower box). Perforated lines indicate the conductance ratio of NR2A/B or NR2C/D receptor induced currents and VMIC derived from oocyte expression data of Kuner and Schoepfer [19].