Region | Putative Role in Pain | Reference |
---|---|---|
Caudate | Involved in avoidance behavior to pain | [169] |
 | Decrease pain sensitivity following apomorphine injections | [14] |
 | Encode noxious stimuli intensity to minimize bodily harm | [9] |
 | Behavioral Reinforcement (? Including Pain) | [3] |
Putamen | Somatotopic modulation of pain | [148] |
 | Variations in subjective ratings of pain | [135] |
Nucleus Accumbens | Affective Valence for Reward and Aversive Stimuli | |
 | Processing of emotional salience of pain | [135] |
Globus Pallidus | Encoding of behavioral repertoires (? Including pain) | [3] |
 | Deep brain stimulation inhibits pain | |
 | Morphine analgesia | [172] |
Subthalamic Nucleus | Functional suppression of neural messages | [173] |
 | Behavioral Inhibition | [174] |
 | Regulates level of execution of cortical commands; processing of emotional, cognitive and motor behavior | [3] |
Substantia Nigra | Heterogeneous response to aversive stimuli | [96] |