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Figure 3 | Molecular Pain

Figure 3

From: p38 mediates mechanical allodynia in a mouse model of type 2 diabetes

Figure 3

Anti-NGF treatment inhibits the phosphorylation of p38 in db/db mice. A: Representative immunoblots of pp38, p38 and actin using LDRG from db+ and db/db mice treated with either control (IgG) or an anti-NGF antibody for 2 wk. Anti-NGF treatment decreased the intensity of pp38 signals in db/db mice but not db+ mice at 8 wk of age. B: Densitometric studies of pp38 immunoblots using LDRG from 8 wk old db+ and db/db mice. A significant decrease in p38 phosphorylation was detected in db/db mice after anti-NGF treatment. N = 4, **p < 0.01

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