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Figure 5 | Molecular Pain

Figure 5

From: p38 mediates mechanical allodynia in a mouse model of type 2 diabetes

Figure 5

SB203580 inhibits the upregulation of COX2, iNOS and TNF-α gene expression. RT-PCR analysis of COX2 (A), iNOS (B) and TNF-α (C) in LDRG of db+ and db/db mice. The gene expression of all three inflammatory mediators was upregulated in LDRG of db/db mice. SB203580 treatment significantly decreased the elevated levels of gene expressions in db/db mice. In addition, SB203580 treatment lowered the gene expression of TNF-α in db+ mice. N = 4, *p < 0.05.

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