Figure 7

SB203580 treatment decreases the expression of iNOS, COX2, and TNF-α in db/db LDRG neurons. The percentages of immunopositive LDRG neurons for iNOS (A), COX2 (B), and TNF-α (C) were measured in db+ and db/db mice. The mice were treated with vehicle control (artificial CSF containing 10% DMSO) or vehicle with SB203580. Significant increases in the percentages for iNOS, COX2, and TNF-α were detected in vehicle-treated db/db mice, in comparison to db+ mice. SB203580 treatment significantly blocks the increased percentages of iNOS, COX2, and TNF-α in db/db mice to levels comparable with the nondiabetic control (db+) mice. N = 4, ***p < 0.001.