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Figure 3 | Molecular Pain

Figure 3

From: Absence of histamine-induced itch in the African naked mole-rat and "rescue" by Substance P

Figure 3

Substance P "rescues" histamine-mediated scratching in naked mole-rats. A, naked mole-rats: after intrathecal administration of saline, intracutaneous histamine fails to evoke any more scratching than saline (black bar vs. grey bar), however after intrathecal SP treatment, histamine evokes robust scratching (red bar). Intrathecal administration of SP alone (green bar) increases scratching compared to spontaneous levels (blue bar), but combining intrathecal SP with subsequent intracutaneous saline induces no greater effect (yellow bar). B, mice: intracutaneous histamine causes increased scratching (black bar) compared to saline alone (grey bar) and is of a similar magnitude following intrathecal SP treatment (red bar). Intrathecal SP administration induces more scratching than is observed spontaneously (green vs. blue bar), but combining intrathecal SP with subsequent intracutaneous saline induces no greater effect (yellow bar). N = 4 animals for each group; it/ic, intrathecal treatment/intracutaneous treatment; sal, saline, hist, histamine, SP, substance P, spont, spontaneous and *, p < 0.05, **, p < 0.01 and ***, p < 0.001.

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