Figure 2
From: Effects of Parecoxib and Fentanyl on nociception-induced cortical activity
Changes in EEG, Vm and waveform correlation during nociceptive stimulation. A, left panel: Nociceptive stimulation reduced normalized total power of each EEG band; right panel: The cumulative power probability of the EEG, was shifted to the right, under nociceptive stimulation. B, left panel: The distribution of membrane potential (Vm), was bimodally distributed under the resting condition, and unimodally distributed when nociceptive stimulation was applied; right panel: The cumulative probability of Vm density is plotted before, after and during nocicptive stimulation. All measures returned to pre-stimulation values after nociceptive stimulation was removed. C and D: Waveform correlation between the ACC and S1 showing that the correlation coefficient decreased during tail pinch; in C extracellular recordings were recorded in both regions, in D intracellular recordings were recorded at S1 while extracellular recordings were recorded at ACC. The left panel in both C and D show a sample correlation coefficient before and during nociceptive stimulation. The right panel plots the group data. Each EEG power was normalized to the total power of Pre-stimulation values. The correlation coefficient (peak value near zero seconds) was considerably higher in the resting state than during tail pinch.