Figure 3
From: Effects of Parecoxib and Fentanyl on nociception-induced cortical activity
The effect of parecoxib and fentanyl is evaluated by EEG parameters. Total power (A) was decreased during nociceptive stimulation, while MF (B), SEF (C), and the distance of cumulative power distribution (CPD) increased in response to noxious stimulation(D). Fentanyl (n = 12) significantly inhibited the response in each case and the inhibition was reversed by naloxone (n = 9). Parecoxib had no effect on the neuronal response to noxious stimulation (n = 11). Total power and distance of cumulative power distribution was normalized to pre-stimulation values. *P < 0.05, **P < 0.01, #P < 0.001, compared with pre-stim value.