Figure 4From: Differential adeno-associated virus mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture Dorsal rhizotomy reduces GFP and SP labeling in spinal cord. GFP- (A and B) and substance P-ir (C and D) in rat lumbar spinal cord. Unilateral dorsal rhizotomy was performed 6 weeks after i.v. mannitol pretreatment and i.t. rAAV5-GFP injection. GFP-ir is reduced ipsilaterally to dorsal rhizotomy (A and B). Reduction in SP-ir in the same section (C and D) demonstrates the efficacy of the surgical procedure.Back to article page