Figure 2From: The val158met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation Boxplot of COMT genotype effect on fMRI BOLD activation in the anterior cingulate cortex (ACC). Median, 25th percentile, 75th percentile, minimum value, maximum value and outliers are shown. 1 The high BOLD activation in response to laser stimulation in this subject was reproduced in a second experiment that was performed two month later (mean Z value in the ACC = 5.3), suggesting that this 'outlier' is reflecting biological variance in the sample and not a measurement error. Furthermore, the genotype effect on ACC activation remained significant, (F = 7.06; p = 0.01; F = 4.92; p = 0.031 age-corrected) even when this subject was excluded from the analysis.Back to article page