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Figure 2 | Molecular Pain

Figure 2

From: The val158met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation

Figure 2

Boxplot of COMT genotype effect on fMRI BOLD activation in the anterior cingulate cortex (ACC). Median, 25th percentile, 75th percentile, minimum value, maximum value and outliers are shown. 1 The high BOLD activation in response to laser stimulation in this subject was reproduced in a second experiment that was performed two month later (mean Z value in the ACC = 5.3), suggesting that this 'outlier' is reflecting biological variance in the sample and not a measurement error. Furthermore, the genotype effect on ACC activation remained significant, (F = 7.06; p = 0.01; F = 4.92; p = 0.031 age-corrected) even when this subject was excluded from the analysis.

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