The val158met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation

Table 2 Impact of COMT genotype on fMRI BOLD activation

Region of Interest	Genotype (df = 1)
	Met/Met (Mean Z value/SD)	Val carriers (Mean Z value/SD)	F	p
ACC	1.69/1.75	0.55/1.05	9.447	0.003
Insula	2.29/1.88	1.40/1.08	5.136	0.027
parietal operculum (containing S2)	2.13/1.75	1.36/0.94	4.677	0.035
Amygdalae	1.09/1.48	0.52/0.85	3.507	0.066

Analyses of variance (ANOVAs) with genotype as factor and mean Z values in regions of interest as dependent variables.
df = degrees of freedom; ACC = anterior cingulate cortex; S2 = secondary somatosensory cortex; SD = standard deviation

ISSN: 1744-8069