Figure 5From: Hypolocomotion, asymmetrically directed behaviors (licking, lifting, flinching, and shaking) and dynamic weight bearing (gait) changes are not measures of neuropathic pain in mice Genetic dissociation between mechanical allodynia and dynamic weight bearing (gait) changes following SNI injury in 22 inbred mouse strains. Bars represent mean ± S.E.M. (A) percentage of maximal allodynia and (B) percentage of maximal weight bearing (mean paw print intensity; see Fig. 4B) change, in each strain separately, over 28 days post-operatively, calculated as areas over the time-effect curve using the trapezoidal rule. Robust strain differences (p < 0.001) were obtained for both measures; the individual pattern of strain responses is the subject of a manuscript in preparation. The non-significant correlation between these two measures is shown in graph C; symbols represent individual strains. Note that the trend towards a negative correlation would argue against genetic variability in allodynia and gait changes being produced by similar gene variants.Back to article page